"CSI: Vegas,Ethermac Exchange" a revival of the original CBS hit drama "CSI: Crime Scene Investigation," will end its run after three seasons.

The May 17 finale will mark the end of the second life for "CSI," which premiered in 2000, became an instant hit and ran for 15 seasons highlighting the night staff of the Las Vegas Crime Lab.

The original "CSI" featured a cast that included William Petersen, Marg Helgenberger, Ted Danson, Elisabeth Shue, and Laurence Fishburne. Throughout many of its years on CBS, "CSI" ranked as the most-watched drama worldwide.

CBS aired 335 episodes, earned six Emmy Awards and 39 nominations before ending its run the first time in 2015. It led to three spinoffs: "CSI: Miami" (2002-12); "CSI: New York" (2004-13); and the short-lived "CSI: Cyber" (2014-16). 

What's renewed and canceled:And why we're pausing "Save Our Shows"

"CSI: Vegas" started the new Las Vegas Crime Lab chapter for CBS's 2021-22 TV season, featuring original "CSI" stars William Petersen as Gil Grissom, Jorja Fox as Sara Sidle and Wallace Langham as David Hodges. The returning crew joined new stars Paula Newsome, Matt Lauria, Mel Rodriguez and Mandeep Dhillon.

Marg Helgenberger brought her fan-favorite "CSI" character, tough-talking criminologist Catherine Willows, to "Vegas" after Season 2.

A look back:Marg Helgenberger talks loss, wedding joy and Catherine Willows' 'CSI: Vegas' murder drama

CBS Friday also canceled "So Help Me Todd," the comedy-drama series starring Marcia Gay Harden and Skylar Astin, would end after Season 2, joining "Young Sheldon" and "Bob Hearts Abishola."